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Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer

Aberrant activation of the Wnt/β-catenin pathway is frequently found in various cancers, often through mutations of downstream components. Inhibiting β-catenin signaling in tumors with downstream pathway mutations remains challenging, due to a lack of favorable targets. On the other hand, targeting...

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Detalles Bibliográficos
Autores principales: Hao, Huai-Xiang, Jiang, Xiaomo, Cong, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931619/
https://www.ncbi.nlm.nih.gov/pubmed/27338477
http://dx.doi.org/10.3390/cancers8060054

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