Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems

Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen u...

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Detalles Bibliográficos
Autores principales: Wen, Ru, Umeano, Afoma C., Francis, Lily, Sharma, Nivita, Tundup, Smanla, Dhar, Shanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931635/
https://www.ncbi.nlm.nih.gov/pubmed/27258316
http://dx.doi.org/10.3390/vaccines4020018
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author Wen, Ru
Umeano, Afoma C.
Francis, Lily
Sharma, Nivita
Tundup, Smanla
Dhar, Shanta
author_facet Wen, Ru
Umeano, Afoma C.
Francis, Lily
Sharma, Nivita
Tundup, Smanla
Dhar, Shanta
author_sort Wen, Ru
collection PubMed
description Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen uptake via prevention of vaccine degradation in the biological environment and the intrinsic immune-stimulatory properties of the materials. Mitochondria play paramount roles in cell life and death and are promising targets for vaccine delivery systems to effectively induce immune responses. In this review, we focus on NPs-based delivery systems with surfaces that can be manipulated by using mitochondria targeting moieties for intervention in health and disease.
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spelling pubmed-49316352016-07-08 Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems Wen, Ru Umeano, Afoma C. Francis, Lily Sharma, Nivita Tundup, Smanla Dhar, Shanta Vaccines (Basel) Review Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen uptake via prevention of vaccine degradation in the biological environment and the intrinsic immune-stimulatory properties of the materials. Mitochondria play paramount roles in cell life and death and are promising targets for vaccine delivery systems to effectively induce immune responses. In this review, we focus on NPs-based delivery systems with surfaces that can be manipulated by using mitochondria targeting moieties for intervention in health and disease. MDPI 2016-06-01 /pmc/articles/PMC4931635/ /pubmed/27258316 http://dx.doi.org/10.3390/vaccines4020018 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wen, Ru
Umeano, Afoma C.
Francis, Lily
Sharma, Nivita
Tundup, Smanla
Dhar, Shanta
Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems
title Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems
title_full Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems
title_fullStr Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems
title_full_unstemmed Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems
title_short Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems
title_sort mitochondrion: a promising target for nanoparticle-based vaccine delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931635/
https://www.ncbi.nlm.nih.gov/pubmed/27258316
http://dx.doi.org/10.3390/vaccines4020018
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