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Vimentin in Bacterial Infections

Despite well-studied bacterial strategies to target actin to subvert the host cell cytoskeleton, thus promoting bacterial survival, replication, and dissemination, relatively little is known about the bacterial interaction with other components of the host cell cytoskeleton, including intermediate f...

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Detalles Bibliográficos
Autores principales: Mak, Tim N., Brüggemann, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931667/
https://www.ncbi.nlm.nih.gov/pubmed/27096872
http://dx.doi.org/10.3390/cells5020018
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author Mak, Tim N.
Brüggemann, Holger
author_facet Mak, Tim N.
Brüggemann, Holger
author_sort Mak, Tim N.
collection PubMed
description Despite well-studied bacterial strategies to target actin to subvert the host cell cytoskeleton, thus promoting bacterial survival, replication, and dissemination, relatively little is known about the bacterial interaction with other components of the host cell cytoskeleton, including intermediate filaments (IFs). IFs have not only roles in maintaining the structural integrity of the cell, but they are also involved in many cellular processes including cell adhesion, immune signaling, and autophagy, processes that are important in the context of bacterial infections. Here, we summarize the knowledge about the role of IFs in bacterial infections, focusing on the type III IF protein vimentin. Recent studies have revealed the involvement of vimentin in host cell defenses, acting as ligand for several pattern recognition receptors of the innate immune system. Two main aspects of bacteria-vimentin interactions are presented in this review: the role of vimentin in pathogen-binding on the cell surface and subsequent bacterial invasion and the interaction of cytosolic vimentin and intracellular pathogens with regards to innate immune signaling. Mechanistic insight is presented involving distinct bacterial virulence factors that target vimentin to subvert its function in order to change the host cell fate in the course of a bacterial infection.
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spelling pubmed-49316672016-07-08 Vimentin in Bacterial Infections Mak, Tim N. Brüggemann, Holger Cells Review Despite well-studied bacterial strategies to target actin to subvert the host cell cytoskeleton, thus promoting bacterial survival, replication, and dissemination, relatively little is known about the bacterial interaction with other components of the host cell cytoskeleton, including intermediate filaments (IFs). IFs have not only roles in maintaining the structural integrity of the cell, but they are also involved in many cellular processes including cell adhesion, immune signaling, and autophagy, processes that are important in the context of bacterial infections. Here, we summarize the knowledge about the role of IFs in bacterial infections, focusing on the type III IF protein vimentin. Recent studies have revealed the involvement of vimentin in host cell defenses, acting as ligand for several pattern recognition receptors of the innate immune system. Two main aspects of bacteria-vimentin interactions are presented in this review: the role of vimentin in pathogen-binding on the cell surface and subsequent bacterial invasion and the interaction of cytosolic vimentin and intracellular pathogens with regards to innate immune signaling. Mechanistic insight is presented involving distinct bacterial virulence factors that target vimentin to subvert its function in order to change the host cell fate in the course of a bacterial infection. MDPI 2016-04-18 /pmc/articles/PMC4931667/ /pubmed/27096872 http://dx.doi.org/10.3390/cells5020018 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mak, Tim N.
Brüggemann, Holger
Vimentin in Bacterial Infections
title Vimentin in Bacterial Infections
title_full Vimentin in Bacterial Infections
title_fullStr Vimentin in Bacterial Infections
title_full_unstemmed Vimentin in Bacterial Infections
title_short Vimentin in Bacterial Infections
title_sort vimentin in bacterial infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931667/
https://www.ncbi.nlm.nih.gov/pubmed/27096872
http://dx.doi.org/10.3390/cells5020018
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