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2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1

2-Aminoethoxydiphenyl borate (2-APB) elicits potentiation current (I(p)) on Ca(2+) release-activated Ca(2+) (CRAC) channels. An accurate investigation into this modulation mechanism would reveal how STIM1-dependent channel gating is enhanced, and benefit the future immune enhancer development. Here,...

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Detalles Bibliográficos
Autores principales:	Xu, Xiaolan, Ali, Sher, Li, Yufeng, Yu, Haijie, Zhang, Mingshu, Lu, Jingze, Xu, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931693/ https://www.ncbi.nlm.nih.gov/pubmed/27373367 http://dx.doi.org/10.1038/srep29304

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