Cargando…

Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis

With the increased availability of laboratory tests, glutamic acid decarboxylase (GAD) antibody-positive limbic encephalitis has become an emerging diagnosis. The myriad symptoms of limbic encephalitis make the diagnosis challenging. Symptoms range from seizures, memory loss, dementia, confusion, to...

Descripción completa

Detalles Bibliográficos
Autores principales: Gardner, Rachael, Rangaswamy, Rajesh, Peng, Yen-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931809/
https://www.ncbi.nlm.nih.gov/pubmed/27429684
http://dx.doi.org/10.14740/jocmr2624w
_version_ 1782440964250402816
author Gardner, Rachael
Rangaswamy, Rajesh
Peng, Yen-Yi
author_facet Gardner, Rachael
Rangaswamy, Rajesh
Peng, Yen-Yi
author_sort Gardner, Rachael
collection PubMed
description With the increased availability of laboratory tests, glutamic acid decarboxylase (GAD) antibody-positive limbic encephalitis has become an emerging diagnosis. The myriad symptoms of limbic encephalitis make the diagnosis challenging. Symptoms range from seizures, memory loss, dementia, confusion, to psychosis. We present a case of a 21-year-old female with GAD65 antibody-positive limbic encephalitis. The case is unique because the clinical course suggests that non-convulsive seizures are the major cause of this patient’s clinical manifestations. The following is the thesis: systemic autoimmune disease, associated with the GAD65 antibody, gives rise to seizures, in particular, non-convulsive seizures. Temporal lobes happen to be the most susceptible sites to develop seizures. The greater part of these seizures can be non-convulsive and hard to recognize without electroencephalogram (EEG) monitoring. The variable symptoms mirror the severity and locations of these seizures. The magnetic resonance imaging (MRI) signal abnormities in the bilateral hippocampus, fornix, and mammillary body correlate with the density of these seizures in the similar manner, which suggests it is secondary to post-ictal edema.
format Online
Article
Text
id pubmed-4931809
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elmer Press
record_format MEDLINE/PubMed
spelling pubmed-49318092016-07-15 Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis Gardner, Rachael Rangaswamy, Rajesh Peng, Yen-Yi J Clin Med Res Case Report With the increased availability of laboratory tests, glutamic acid decarboxylase (GAD) antibody-positive limbic encephalitis has become an emerging diagnosis. The myriad symptoms of limbic encephalitis make the diagnosis challenging. Symptoms range from seizures, memory loss, dementia, confusion, to psychosis. We present a case of a 21-year-old female with GAD65 antibody-positive limbic encephalitis. The case is unique because the clinical course suggests that non-convulsive seizures are the major cause of this patient’s clinical manifestations. The following is the thesis: systemic autoimmune disease, associated with the GAD65 antibody, gives rise to seizures, in particular, non-convulsive seizures. Temporal lobes happen to be the most susceptible sites to develop seizures. The greater part of these seizures can be non-convulsive and hard to recognize without electroencephalogram (EEG) monitoring. The variable symptoms mirror the severity and locations of these seizures. The magnetic resonance imaging (MRI) signal abnormities in the bilateral hippocampus, fornix, and mammillary body correlate with the density of these seizures in the similar manner, which suggests it is secondary to post-ictal edema. Elmer Press 2016-08 2016-07-01 /pmc/articles/PMC4931809/ /pubmed/27429684 http://dx.doi.org/10.14740/jocmr2624w Text en Copyright 2016, Gardner et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gardner, Rachael
Rangaswamy, Rajesh
Peng, Yen-Yi
Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis
title Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis
title_full Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis
title_fullStr Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis
title_full_unstemmed Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis
title_short Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis
title_sort correlations of clusters of non-convulsive seizure and magnetic resonance imaging in a case with gad65-positive autoimmune limbic encephalitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931809/
https://www.ncbi.nlm.nih.gov/pubmed/27429684
http://dx.doi.org/10.14740/jocmr2624w
work_keys_str_mv AT gardnerrachael correlationsofclustersofnonconvulsiveseizureandmagneticresonanceimaginginacasewithgad65positiveautoimmunelimbicencephalitis
AT rangaswamyrajesh correlationsofclustersofnonconvulsiveseizureandmagneticresonanceimaginginacasewithgad65positiveautoimmunelimbicencephalitis
AT pengyenyi correlationsofclustersofnonconvulsiveseizureandmagneticresonanceimaginginacasewithgad65positiveautoimmunelimbicencephalitis