Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan

Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothes...

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Detalles Bibliográficos
Autores principales: Patrick, Alison, Seluanov, Michael, Hwang, Chaewon, Tam, Jonathan, Khan, Tanya, Morgenstern, Ari, Wiener, Lauren, Vazquez, Juan M., Zafar, Hiba, Wen, Robert, Muratkalyeva, Malika, Doerig, Katherine, Zagorulya, Maria, Cole, Lauren, Catalano, Sophia, Lobo Ladd, Aliny AB, Coppi, A. Augusto, Coşkun, Yüksel, Tian, Xiao, Ablaeva, Julia, Nevo, Eviatar, Gladyshev, Vadim N., Zhang, Zhengdong D., Vijg, Jan, Seluanov, Andrei, Gorbunova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931838/
https://www.ncbi.nlm.nih.gov/pubmed/27163160
http://dx.doi.org/10.18632/aging.100958

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