Cargando…

Exercise: a “new drug” for elderly patients with chronic heart failure

Patients with chronic heart failure (CHF) experience progressive deterioration of functional capacity and quality of life (QoL). This prospective, randomized, controlled trial assesses the effect of exercise training (ET) protocol on functional capacity, rehospitalization, and QoL in CHF patients ol...

Descripción completa

Detalles Bibliográficos
Autores principales: Antonicelli, Roberto, Spazzafumo, Liana, Scalvini, Simonetta, Olivieri, Fabiola, Matassini, Maria Vittoria, Parati, Gianfranco, Del Sindaco, Donatella, Gallo, Raffaella, Lattanzio, Fabrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931840/
https://www.ncbi.nlm.nih.gov/pubmed/26953895
http://dx.doi.org/10.18632/aging.100901
_version_ 1782440969709289472
author Antonicelli, Roberto
Spazzafumo, Liana
Scalvini, Simonetta
Olivieri, Fabiola
Matassini, Maria Vittoria
Parati, Gianfranco
Del Sindaco, Donatella
Gallo, Raffaella
Lattanzio, Fabrizia
author_facet Antonicelli, Roberto
Spazzafumo, Liana
Scalvini, Simonetta
Olivieri, Fabiola
Matassini, Maria Vittoria
Parati, Gianfranco
Del Sindaco, Donatella
Gallo, Raffaella
Lattanzio, Fabrizia
author_sort Antonicelli, Roberto
collection PubMed
description Patients with chronic heart failure (CHF) experience progressive deterioration of functional capacity and quality of life (QoL). This prospective, randomized, controlled trial assesses the effect of exercise training (ET) protocol on functional capacity, rehospitalization, and QoL in CHF patients older than 70 years compared with a control group. A total of 343 elderly patients with stable CHF (age, 76.90±5.67, men, 195, 56.9%) were randomized to ET (TCG, n=170) or usual care (UCG, n=173). The ET protocol involved supervised training sessions for 3 months in the hospital followed by home-telemonitored sessions for 3 months. Assessments, performed at baseline and at 3 and 6 months, included: ECG, resting echocardiography, NT-proBNP, 6-minute walk test (6MWT), Minnesota Living with Heart Failure Questionnaire, and comprehensive geriatric assessment with the InterRAI-HC instrument. As compared to UCG, ET patients at 6 months showed: i) significantly increased 6MWT distance (450±83 vs. 290±97 m, p<0.001); ii) increased ADL scores (5.00±2.49 vs. 6.94±5.66, p=0.037); iii) 40% reduced risk of rehospitalisation (hazard ratio=0.558, 95%CI, 0.326-0.954, p=0.033); and iv) significantly improved perceived QoL (28.6±12.3 vs. 44.5±12.3, p<0.001). In hospital and home-based telemonitored exercise confer significant benefits on the oldest CHF patients, improving functional capacity and subjective QoL and reducing risk of rehospitalisation.
format Online
Article
Text
id pubmed-4931840
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-49318402016-07-18 Exercise: a “new drug” for elderly patients with chronic heart failure Antonicelli, Roberto Spazzafumo, Liana Scalvini, Simonetta Olivieri, Fabiola Matassini, Maria Vittoria Parati, Gianfranco Del Sindaco, Donatella Gallo, Raffaella Lattanzio, Fabrizia Aging (Albany NY) Research Paper Patients with chronic heart failure (CHF) experience progressive deterioration of functional capacity and quality of life (QoL). This prospective, randomized, controlled trial assesses the effect of exercise training (ET) protocol on functional capacity, rehospitalization, and QoL in CHF patients older than 70 years compared with a control group. A total of 343 elderly patients with stable CHF (age, 76.90±5.67, men, 195, 56.9%) were randomized to ET (TCG, n=170) or usual care (UCG, n=173). The ET protocol involved supervised training sessions for 3 months in the hospital followed by home-telemonitored sessions for 3 months. Assessments, performed at baseline and at 3 and 6 months, included: ECG, resting echocardiography, NT-proBNP, 6-minute walk test (6MWT), Minnesota Living with Heart Failure Questionnaire, and comprehensive geriatric assessment with the InterRAI-HC instrument. As compared to UCG, ET patients at 6 months showed: i) significantly increased 6MWT distance (450±83 vs. 290±97 m, p<0.001); ii) increased ADL scores (5.00±2.49 vs. 6.94±5.66, p=0.037); iii) 40% reduced risk of rehospitalisation (hazard ratio=0.558, 95%CI, 0.326-0.954, p=0.033); and iv) significantly improved perceived QoL (28.6±12.3 vs. 44.5±12.3, p<0.001). In hospital and home-based telemonitored exercise confer significant benefits on the oldest CHF patients, improving functional capacity and subjective QoL and reducing risk of rehospitalisation. Impact Journals LLC 2016-03-04 /pmc/articles/PMC4931840/ /pubmed/26953895 http://dx.doi.org/10.18632/aging.100901 Text en Copyright: © 2016 Antonicelli et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Antonicelli, Roberto
Spazzafumo, Liana
Scalvini, Simonetta
Olivieri, Fabiola
Matassini, Maria Vittoria
Parati, Gianfranco
Del Sindaco, Donatella
Gallo, Raffaella
Lattanzio, Fabrizia
Exercise: a “new drug” for elderly patients with chronic heart failure
title Exercise: a “new drug” for elderly patients with chronic heart failure
title_full Exercise: a “new drug” for elderly patients with chronic heart failure
title_fullStr Exercise: a “new drug” for elderly patients with chronic heart failure
title_full_unstemmed Exercise: a “new drug” for elderly patients with chronic heart failure
title_short Exercise: a “new drug” for elderly patients with chronic heart failure
title_sort exercise: a “new drug” for elderly patients with chronic heart failure
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931840/
https://www.ncbi.nlm.nih.gov/pubmed/26953895
http://dx.doi.org/10.18632/aging.100901
work_keys_str_mv AT antonicelliroberto exerciseanewdrugforelderlypatientswithchronicheartfailure
AT spazzafumoliana exerciseanewdrugforelderlypatientswithchronicheartfailure
AT scalvinisimonetta exerciseanewdrugforelderlypatientswithchronicheartfailure
AT olivierifabiola exerciseanewdrugforelderlypatientswithchronicheartfailure
AT matassinimariavittoria exerciseanewdrugforelderlypatientswithchronicheartfailure
AT paratigianfranco exerciseanewdrugforelderlypatientswithchronicheartfailure
AT delsindacodonatella exerciseanewdrugforelderlypatientswithchronicheartfailure
AT galloraffaella exerciseanewdrugforelderlypatientswithchronicheartfailure
AT lattanziofabrizia exerciseanewdrugforelderlypatientswithchronicheartfailure