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Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart

Insulin protects cardiomyocytes from myocardial ischemia/reperfusion (MI/R) injury through activating Akt. However, phosphatase PHLPP-1 (PH domain leucine-rich repeat protein phosphatase-1) dephosphorylates and inactivates Akt. The balanced competitive interaction of insulin and PHLPP-1 has not been...

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Detalles Bibliográficos
Autores principales:	Xing, Yuan, Sun, Wanqing, Wang, Yishi, Gao, Feng, Ma, Heng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931841/ https://www.ncbi.nlm.nih.gov/pubmed/27019292 http://dx.doi.org/10.18632/aging.100933

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