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Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

Reprogramming of somatic cells into a pluripotent state is known to be accompanied by extensive restructuring of mitochondria and switch in metabolic requirements. Here we utilized Leber's hereditary optic neuropathy (LHON) as a mitochondrial disease model to study the effects of homoplasmic mt...

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Detalles Bibliográficos
Autores principales:	Hung, Sandy S.C., Van Bergen, Nicole J., Jackson, Stacey, Liang, Helena, Mackey, David A., Hernández, Damián, Lim, Shiang Y., Hewitt, Alex W., Trounce, Ian, Pébay, Alice, Wong, Raymond C.B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931846/ https://www.ncbi.nlm.nih.gov/pubmed/27127184 http://dx.doi.org/10.18632/aging.100950

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