Rapamycin reverses the senescent phenotype and improves immuno-regulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway

We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE. The aim of this study was to investigate the effects of rapamycin (RAPA) on the senescences and immunoregulatory ability of MSCs of M...

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Detalles Bibliográficos
Autores principales: Gu, Zhifeng, Tan, Wei, Ji, Juan, Feng, Guijian, Meng, Yan, Da, Zhanyun, Guo, Genkai, Xia, Yunfei, Zhu, Xinhang, Shi, Guixiu, Cheng, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931856/
https://www.ncbi.nlm.nih.gov/pubmed/27048648
http://dx.doi.org/10.18632/aging.100925

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