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Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

BACKGROUND: We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested...

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Autores principales: McClelland, Ruth, Christensen, Kelly, Mohammed, Suhaib, McGuinness, Dagmara, Cooney, Josephine, Bakshi, Andisheh, Demou, Evangelia, MacDonald, Ewan, Caslake, Muriel, Stenvinkel, Peter, Shiels, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931858/
https://www.ncbi.nlm.nih.gov/pubmed/27132985
http://dx.doi.org/10.18632/aging.100948
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author McClelland, Ruth
Christensen, Kelly
Mohammed, Suhaib
McGuinness, Dagmara
Cooney, Josephine
Bakshi, Andisheh
Demou, Evangelia
MacDonald, Ewan
Caslake, Muriel
Stenvinkel, Peter
Shiels, Paul G.
author_facet McClelland, Ruth
Christensen, Kelly
Mohammed, Suhaib
McGuinness, Dagmara
Cooney, Josephine
Bakshi, Andisheh
Demou, Evangelia
MacDonald, Ewan
Caslake, Muriel
Stenvinkel, Peter
Shiels, Paul G.
author_sort McClelland, Ruth
collection PubMed
description BACKGROUND: We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health. RESULTS: We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption. CONCLUSIONS: Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.
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spelling pubmed-49318582016-07-18 Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake McClelland, Ruth Christensen, Kelly Mohammed, Suhaib McGuinness, Dagmara Cooney, Josephine Bakshi, Andisheh Demou, Evangelia MacDonald, Ewan Caslake, Muriel Stenvinkel, Peter Shiels, Paul G. Aging (Albany NY) Research Paper BACKGROUND: We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health. RESULTS: We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption. CONCLUSIONS: Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status. Impact Journals LLC 2016-04-26 /pmc/articles/PMC4931858/ /pubmed/27132985 http://dx.doi.org/10.18632/aging.100948 Text en Copyright: © 2016 McClelland et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
McClelland, Ruth
Christensen, Kelly
Mohammed, Suhaib
McGuinness, Dagmara
Cooney, Josephine
Bakshi, Andisheh
Demou, Evangelia
MacDonald, Ewan
Caslake, Muriel
Stenvinkel, Peter
Shiels, Paul G.
Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
title Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
title_full Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
title_fullStr Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
title_full_unstemmed Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
title_short Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
title_sort accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931858/
https://www.ncbi.nlm.nih.gov/pubmed/27132985
http://dx.doi.org/10.18632/aging.100948
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