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Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle

The multidrug transporter P-glycoprotein (P-gp, ABCB1) is an ATP-dependent pump that mediates the efflux of structurally diverse drugs and xenobiotics across cell membranes, affecting drug pharmacokinetics and contributing to the development of multidrug resistance. Structural information about the...

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Detalles Bibliográficos
Autores principales:	Frank, Gabriel A., Shukla, Suneet, Rao, Prashant, Borgnia, Mario J., Bartesaghi, Alberto, Merk, Alan, Mobin, Aerfa, Esser, Lothar, Earl, Lesley A., Gottesman, Michael M., Xia, Di, Ambudkar, Suresh V., Subramaniam, Sriram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:	Accelerated Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931865/ https://www.ncbi.nlm.nih.gov/pubmed/27190212 http://dx.doi.org/10.1124/mol.116.104190

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