5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA

CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T mutation rate in CpG sites has been related to 5-methylcytosine (5mC), an epigenetically modified base which resides in CpGs and plays a role in transcription silencing. In brain nearly a third of...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomkova, Marketa, McClellan, Michael, Kriaucionis, Skirmantas, Schuster-Boeckler, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931910/
https://www.ncbi.nlm.nih.gov/pubmed/27183007
http://dx.doi.org/10.7554/eLife.17082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931910/
https://www.ncbi.nlm.nih.gov/pubmed/27183007
http://dx.doi.org/10.7554/eLife.17082

Ejemplares similares