Temporal regulation of EGF signaling networks by the scaffold protein Shc1

Cell-surface receptors frequently employ scaffold proteins to recruit cytoplasmic targets, but the rationale for this is uncertain. Activated receptor tyrosine kinases, for example, engage scaffolds such as Shc1 that contain phosphotyrosine (pTyr) binding (PTB) domains. Using quantitative mass spect...

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Detalles Bibliográficos
Autores principales: Zheng, Yong, Zhang, Cunjie, Croucher, David R., Soliman, Mohamed A., St-Denis, Nicole, Pasculescu, Adrian, Taylor, Lorne, Tate, Stephen A., Hardy, Rod W., Colwill, Karen, Dai, Anna Yue, Bagshaw, Rick, Dennis, James W., Gingras, Anne-Claude, Daly, Roger J., Pawson, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931914/
https://www.ncbi.nlm.nih.gov/pubmed/23846654
http://dx.doi.org/10.1038/nature12308

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