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Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations
Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temeph...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932163/ https://www.ncbi.nlm.nih.gov/pubmed/27419140 http://dx.doi.org/10.1155/2016/8603263 |
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author | Bellinato, Diogo Fernandes Viana-Medeiros, Priscila Fernandes Araújo, Simone Costa Martins, Ademir J. Lima, José Bento Pereira Valle, Denise |
author_facet | Bellinato, Diogo Fernandes Viana-Medeiros, Priscila Fernandes Araújo, Simone Costa Martins, Ademir J. Lima, José Bento Pereira Valle, Denise |
author_sort | Bellinato, Diogo Fernandes |
collection | PubMed |
description | Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temephos (OP), deltamethrin (PY), and diflubenzuron (IGR) of A. aegypti samples from 12 municipalities distributed throughout the country, collected between 2010 and 2012. High levels of resistance to neurotoxic insecticides were detected in almost all populations: RR(95) to temephos varied between 4.0 and 27.1; the lowest RR(95) to deltamethrin was 13.1, and values higher than 70.0 were found. In contrast, all samples were susceptible to diflubenzuron (RR(95) < 2.3). Biochemical tests performed with larvae and adults discarded the participation of acetylcholinesterase, the OP target, and confirmed involvement of the detoxifying enzymes esterases, mixed function oxidases, and glutathione-S-transferases. The results obtained were discussed taking into account the public chemical control component and the increase in the domestic use of insecticides during dengue epidemic seasons in the evaluated municipalities. |
format | Online Article Text |
id | pubmed-4932163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49321632016-07-14 Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations Bellinato, Diogo Fernandes Viana-Medeiros, Priscila Fernandes Araújo, Simone Costa Martins, Ademir J. Lima, José Bento Pereira Valle, Denise Biomed Res Int Research Article Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temephos (OP), deltamethrin (PY), and diflubenzuron (IGR) of A. aegypti samples from 12 municipalities distributed throughout the country, collected between 2010 and 2012. High levels of resistance to neurotoxic insecticides were detected in almost all populations: RR(95) to temephos varied between 4.0 and 27.1; the lowest RR(95) to deltamethrin was 13.1, and values higher than 70.0 were found. In contrast, all samples were susceptible to diflubenzuron (RR(95) < 2.3). Biochemical tests performed with larvae and adults discarded the participation of acetylcholinesterase, the OP target, and confirmed involvement of the detoxifying enzymes esterases, mixed function oxidases, and glutathione-S-transferases. The results obtained were discussed taking into account the public chemical control component and the increase in the domestic use of insecticides during dengue epidemic seasons in the evaluated municipalities. Hindawi Publishing Corporation 2016 2016-06-21 /pmc/articles/PMC4932163/ /pubmed/27419140 http://dx.doi.org/10.1155/2016/8603263 Text en Copyright © 2016 Diogo Fernandes Bellinato et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bellinato, Diogo Fernandes Viana-Medeiros, Priscila Fernandes Araújo, Simone Costa Martins, Ademir J. Lima, José Bento Pereira Valle, Denise Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations |
title | Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations |
title_full | Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations |
title_fullStr | Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations |
title_full_unstemmed | Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations |
title_short | Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations |
title_sort | resistance status to the insecticides temephos, deltamethrin, and diflubenzuron in brazilian aedes aegypti populations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932163/ https://www.ncbi.nlm.nih.gov/pubmed/27419140 http://dx.doi.org/10.1155/2016/8603263 |
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