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Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice

The cytoplasmic phosphatase, protein tyrosine phosphatase nonreceptor type 22 (PTPN22), is a negative regulator of T cell signaling. Genome-wide association studies have shown that single-nucleotide polymorphisms in PTPN22 confer an increased risk of developing multiple autoimmune diseases in humans...

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Detalles Bibliográficos
Autores principales:	Sood, Shatakshi, Brownlie, Rebecca J., Garcia, Celine, Cowan, Graeme, Salmond, Robert J., Sakaguchi, Shimon, Zamoyska, Rose
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2016
Materias:	Autoimmunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932175/ https://www.ncbi.nlm.nih.gov/pubmed/27288531 http://dx.doi.org/10.4049/jimmunol.1502656

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