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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932178/ https://www.ncbi.nlm.nih.gov/pubmed/27363682 http://dx.doi.org/10.1038/ncomms12050 |
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| author | Mitchell, Jonathan S. Li, Ni Weinhold, Niels Försti, Asta Ali, Mina van Duin, Mark Thorleifsson, Gudmar Johnson, David C. Chen, Bowang Halvarsson, Britt-Marie Gudbjartsson, Daniel F. Kuiper, Rowan Stephens, Owen W. Bertsch, Uta Broderick, Peter Campo, Chiara Einsele, Hermann Gregory, Walter A. Gullberg, Urban Henrion, Marc Hillengass, Jens Hoffmann, Per Jackson, Graham H. Johnsson, Ellinor Jöud, Magnus Kristinsson, Sigurður Y. Lenhoff, Stig Lenive, Oleg Mellqvist, Ulf-Henrik Migliorini, Gabriele Nahi, Hareth Nelander, Sven Nickel, Jolanta Nöthen, Markus M. Rafnar, Thorunn Ross, Fiona M. da Silva Filho, Miguel Inacio Swaminathan, Bhairavi Thomsen, Hauke Turesson, Ingemar Vangsted, Annette Vogel, Ulla Waage, Anders Walker, Brian A. Wihlborg, Anna-Karin Broyl, Annemiek Davies, Faith E. Thorsteinsdottir, Unnur Langer, Christian Hansson, Markus Kaiser, Martin Sonneveld, Pieter Stefansson, Kari Morgan, Gareth J. Goldschmidt, Hartmut Hemminki, Kari Nilsson, Björn Houlston, Richard S. |
| author_facet | Mitchell, Jonathan S. Li, Ni Weinhold, Niels Försti, Asta Ali, Mina van Duin, Mark Thorleifsson, Gudmar Johnson, David C. Chen, Bowang Halvarsson, Britt-Marie Gudbjartsson, Daniel F. Kuiper, Rowan Stephens, Owen W. Bertsch, Uta Broderick, Peter Campo, Chiara Einsele, Hermann Gregory, Walter A. Gullberg, Urban Henrion, Marc Hillengass, Jens Hoffmann, Per Jackson, Graham H. Johnsson, Ellinor Jöud, Magnus Kristinsson, Sigurður Y. Lenhoff, Stig Lenive, Oleg Mellqvist, Ulf-Henrik Migliorini, Gabriele Nahi, Hareth Nelander, Sven Nickel, Jolanta Nöthen, Markus M. Rafnar, Thorunn Ross, Fiona M. da Silva Filho, Miguel Inacio Swaminathan, Bhairavi Thomsen, Hauke Turesson, Ingemar Vangsted, Annette Vogel, Ulla Waage, Anders Walker, Brian A. Wihlborg, Anna-Karin Broyl, Annemiek Davies, Faith E. Thorsteinsdottir, Unnur Langer, Christian Hansson, Markus Kaiser, Martin Sonneveld, Pieter Stefansson, Kari Morgan, Gareth J. Goldschmidt, Hartmut Hemminki, Kari Nilsson, Björn Houlston, Richard S. |
| author_sort | Mitchell, Jonathan S. |
| collection | PubMed |
| description | Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(−8)), 6q21 (rs9372120, P=9.09 × 10(−15)), 7q36.1 (rs7781265, P=9.71 × 10(−9)), 8q24.21 (rs1948915, P=4.20 × 10(−11)), 9p21.3 (rs2811710, P=1.72 × 10(−13)), 10p12.1 (rs2790457, P=1.77 × 10(−8)), 16q23.1 (rs7193541, P=5.00 × 10(−12)) and 20q13.13 (rs6066835, P=1.36 × 10(−13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development. |
| format | Online Article Text |
| id | pubmed-4932178 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49321782016-07-12 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma Mitchell, Jonathan S. Li, Ni Weinhold, Niels Försti, Asta Ali, Mina van Duin, Mark Thorleifsson, Gudmar Johnson, David C. Chen, Bowang Halvarsson, Britt-Marie Gudbjartsson, Daniel F. Kuiper, Rowan Stephens, Owen W. Bertsch, Uta Broderick, Peter Campo, Chiara Einsele, Hermann Gregory, Walter A. Gullberg, Urban Henrion, Marc Hillengass, Jens Hoffmann, Per Jackson, Graham H. Johnsson, Ellinor Jöud, Magnus Kristinsson, Sigurður Y. Lenhoff, Stig Lenive, Oleg Mellqvist, Ulf-Henrik Migliorini, Gabriele Nahi, Hareth Nelander, Sven Nickel, Jolanta Nöthen, Markus M. Rafnar, Thorunn Ross, Fiona M. da Silva Filho, Miguel Inacio Swaminathan, Bhairavi Thomsen, Hauke Turesson, Ingemar Vangsted, Annette Vogel, Ulla Waage, Anders Walker, Brian A. Wihlborg, Anna-Karin Broyl, Annemiek Davies, Faith E. Thorsteinsdottir, Unnur Langer, Christian Hansson, Markus Kaiser, Martin Sonneveld, Pieter Stefansson, Kari Morgan, Gareth J. Goldschmidt, Hartmut Hemminki, Kari Nilsson, Björn Houlston, Richard S. Nat Commun Article Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(−8)), 6q21 (rs9372120, P=9.09 × 10(−15)), 7q36.1 (rs7781265, P=9.71 × 10(−9)), 8q24.21 (rs1948915, P=4.20 × 10(−11)), 9p21.3 (rs2811710, P=1.72 × 10(−13)), 10p12.1 (rs2790457, P=1.77 × 10(−8)), 16q23.1 (rs7193541, P=5.00 × 10(−12)) and 20q13.13 (rs6066835, P=1.36 × 10(−13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development. Nature Publishing Group 2016-07-01 /pmc/articles/PMC4932178/ /pubmed/27363682 http://dx.doi.org/10.1038/ncomms12050 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Mitchell, Jonathan S. Li, Ni Weinhold, Niels Försti, Asta Ali, Mina van Duin, Mark Thorleifsson, Gudmar Johnson, David C. Chen, Bowang Halvarsson, Britt-Marie Gudbjartsson, Daniel F. Kuiper, Rowan Stephens, Owen W. Bertsch, Uta Broderick, Peter Campo, Chiara Einsele, Hermann Gregory, Walter A. Gullberg, Urban Henrion, Marc Hillengass, Jens Hoffmann, Per Jackson, Graham H. Johnsson, Ellinor Jöud, Magnus Kristinsson, Sigurður Y. Lenhoff, Stig Lenive, Oleg Mellqvist, Ulf-Henrik Migliorini, Gabriele Nahi, Hareth Nelander, Sven Nickel, Jolanta Nöthen, Markus M. Rafnar, Thorunn Ross, Fiona M. da Silva Filho, Miguel Inacio Swaminathan, Bhairavi Thomsen, Hauke Turesson, Ingemar Vangsted, Annette Vogel, Ulla Waage, Anders Walker, Brian A. Wihlborg, Anna-Karin Broyl, Annemiek Davies, Faith E. Thorsteinsdottir, Unnur Langer, Christian Hansson, Markus Kaiser, Martin Sonneveld, Pieter Stefansson, Kari Morgan, Gareth J. Goldschmidt, Hartmut Hemminki, Kari Nilsson, Björn Houlston, Richard S. Genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
| title | Genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
| title_full | Genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
| title_fullStr | Genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
| title_full_unstemmed | Genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
| title_short | Genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
| title_sort | genome-wide association study identifies multiple susceptibility loci for multiple myeloma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932178/ https://www.ncbi.nlm.nih.gov/pubmed/27363682 http://dx.doi.org/10.1038/ncomms12050 |
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