Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases – structural determination of the lactoperoxidase–methimazole complex at 1.97 Å resolution

Lactoperoxidase (LPO, EC 1.11.1.7) is a member of the mammalian heme peroxidase family which also includes thyroid peroxidase (TPO). These two enzymes have a sequence homology of 76%. The structure of LPO is known but not that of TPO. In order to determine the mode of binding of antithyroid drugs to...

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Detalles Bibliográficos
Autores principales: Singh, Rashmi Prabha, Singh, Avinash, Sirohi, Harsh Vardhan, Singh, Amit Kumar, Kaur, Punit, Sharma, Sujata, Singh, Tej P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932444/
https://www.ncbi.nlm.nih.gov/pubmed/27398304
http://dx.doi.org/10.1002/2211-5463.12051

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