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Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37

Celastrol, a natural compound derived from the Chinese herb Tripterygium wilfordii Hook F, has been proven to inhibit heat shock protein 90 (HSP90) activity and has attracted much attention because of its promising effects in cancer treatment and in ameliorating degenerative neuron diseases. However...

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Detalles Bibliográficos
Autores principales:	Peng, Bin, Gu, Yi‐Jun, Wang, Ying, Cao, Fan‐Fan, Zhang, Xue, Zhang, Deng‐Hai, Hou, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932452/ https://www.ncbi.nlm.nih.gov/pubmed/27398312 http://dx.doi.org/10.1002/2211-5463.12081

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