Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model

The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carc...

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Autores principales: Liang, Yu, Zhu, Fengyu, Zhang, Haojie, Chen, Demeng, Zhang, Xiuhong, Gao, Qian, Li, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932495/
https://www.ncbi.nlm.nih.gov/pubmed/27378170
http://dx.doi.org/10.1038/srep29479
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author Liang, Yu
Zhu, Fengyu
Zhang, Haojie
Chen, Demeng
Zhang, Xiuhong
Gao, Qian
Li, Yang
author_facet Liang, Yu
Zhu, Fengyu
Zhang, Haojie
Chen, Demeng
Zhang, Xiuhong
Gao, Qian
Li, Yang
author_sort Liang, Yu
collection PubMed
description The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We found the ablation of TGF-β signaling could inhibit the cancer cell proliferation, cancer stem cell population and EMT, hence suppressed the invasive cancer progression, which is similar with the result of TGF-β receptor I inhibitor treatment. These findings recognize the roles and mechanisms of TGF-β signaling in bladder cancer progression in vivo for the first time.
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spelling pubmed-49324952016-07-06 Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model Liang, Yu Zhu, Fengyu Zhang, Haojie Chen, Demeng Zhang, Xiuhong Gao, Qian Li, Yang Sci Rep Article The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We found the ablation of TGF-β signaling could inhibit the cancer cell proliferation, cancer stem cell population and EMT, hence suppressed the invasive cancer progression, which is similar with the result of TGF-β receptor I inhibitor treatment. These findings recognize the roles and mechanisms of TGF-β signaling in bladder cancer progression in vivo for the first time. Nature Publishing Group 2016-07-05 /pmc/articles/PMC4932495/ /pubmed/27378170 http://dx.doi.org/10.1038/srep29479 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liang, Yu
Zhu, Fengyu
Zhang, Haojie
Chen, Demeng
Zhang, Xiuhong
Gao, Qian
Li, Yang
Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
title Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
title_full Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
title_fullStr Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
title_full_unstemmed Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
title_short Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
title_sort conditional ablation of tgf-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932495/
https://www.ncbi.nlm.nih.gov/pubmed/27378170
http://dx.doi.org/10.1038/srep29479
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