How Efficient Is My (Medicinal) Chemistry?

“Greening” a chemical transformation is not about only changing the nature of a solvent or decreasing the reaction temperature. There are metrics enabling a critical quantification of the efficiency of an experimental protocol. Some of them are applied to different sequences for the preparation of p...

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Detalles Bibliográficos
Autor principal: Vanden Eynde, Jean Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932544/
https://www.ncbi.nlm.nih.gov/pubmed/27196914
http://dx.doi.org/10.3390/ph9020026
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author Vanden Eynde, Jean Jacques
author_facet Vanden Eynde, Jean Jacques
author_sort Vanden Eynde, Jean Jacques
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description “Greening” a chemical transformation is not about only changing the nature of a solvent or decreasing the reaction temperature. There are metrics enabling a critical quantification of the efficiency of an experimental protocol. Some of them are applied to different sequences for the preparation of paracetamol in order to understand their performance parameters and elucidate pathways for improvement.
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spelling pubmed-49325442016-07-13 How Efficient Is My (Medicinal) Chemistry? Vanden Eynde, Jean Jacques Pharmaceuticals (Basel) Review “Greening” a chemical transformation is not about only changing the nature of a solvent or decreasing the reaction temperature. There are metrics enabling a critical quantification of the efficiency of an experimental protocol. Some of them are applied to different sequences for the preparation of paracetamol in order to understand their performance parameters and elucidate pathways for improvement. MDPI 2016-05-16 /pmc/articles/PMC4932544/ /pubmed/27196914 http://dx.doi.org/10.3390/ph9020026 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vanden Eynde, Jean Jacques
How Efficient Is My (Medicinal) Chemistry?
title How Efficient Is My (Medicinal) Chemistry?
title_full How Efficient Is My (Medicinal) Chemistry?
title_fullStr How Efficient Is My (Medicinal) Chemistry?
title_full_unstemmed How Efficient Is My (Medicinal) Chemistry?
title_short How Efficient Is My (Medicinal) Chemistry?
title_sort how efficient is my (medicinal) chemistry?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932544/
https://www.ncbi.nlm.nih.gov/pubmed/27196914
http://dx.doi.org/10.3390/ph9020026
work_keys_str_mv AT vandeneyndejeanjacques howefficientismymedicinalchemistry

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