Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau

Alzheimer’s disease (AD) and a subset of frontotemporal dementia termed FTLD-Tau are characterized by a massive, yet incompletely characterized and understood redistribution of Tau. To establish a framework for understanding this pathology, we used the genome-editing tool TALEN and generated Tau-mEO...

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Detalles Bibliográficos
Autores principales: Di Xia, Gutmann, Julia M., Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932628/
https://www.ncbi.nlm.nih.gov/pubmed/27378256
http://dx.doi.org/10.1038/srep29074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932628/
https://www.ncbi.nlm.nih.gov/pubmed/27378256
http://dx.doi.org/10.1038/srep29074

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