The emergence and outbreak of multidrug-resistant typhoid fever in China

Typhoid fever remains a severe public health problem in developing countries. The emergence of resistant typhoid, particularly multidrug-resistant typhoid infections, highlights the necessity of monitoring the resistance characteristics of this invasive pathogen. In this study, we report a typhoid f...

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Detalles Bibliográficos
Autores principales: Yan, Meiying, Li, Xinlan, Liao, Qiaohong, Li, Fang, Zhang, Jing, Kan, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932652/
https://www.ncbi.nlm.nih.gov/pubmed/27329848
http://dx.doi.org/10.1038/emi.2016.62
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author Yan, Meiying
Li, Xinlan
Liao, Qiaohong
Li, Fang
Zhang, Jing
Kan, Biao
author_facet Yan, Meiying
Li, Xinlan
Liao, Qiaohong
Li, Fang
Zhang, Jing
Kan, Biao
author_sort Yan, Meiying
collection PubMed
description Typhoid fever remains a severe public health problem in developing countries. The emergence of resistant typhoid, particularly multidrug-resistant typhoid infections, highlights the necessity of monitoring the resistance characteristics of this invasive pathogen. In this study, we report a typhoid fever outbreak caused by multidrug-resistant Salmonella enterica serovar Typhi strains with an ACSSxtT pattern. Resistance genes conferring these phenotypes were harbored by a large conjugative plasmid, which increases the threat of Salmonella Typhi and thus requires close surveillance for dissemination of strains containing such genes.
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spelling pubmed-49326522016-07-14 The emergence and outbreak of multidrug-resistant typhoid fever in China Yan, Meiying Li, Xinlan Liao, Qiaohong Li, Fang Zhang, Jing Kan, Biao Emerg Microbes Infect Original Article Typhoid fever remains a severe public health problem in developing countries. The emergence of resistant typhoid, particularly multidrug-resistant typhoid infections, highlights the necessity of monitoring the resistance characteristics of this invasive pathogen. In this study, we report a typhoid fever outbreak caused by multidrug-resistant Salmonella enterica serovar Typhi strains with an ACSSxtT pattern. Resistance genes conferring these phenotypes were harbored by a large conjugative plasmid, which increases the threat of Salmonella Typhi and thus requires close surveillance for dissemination of strains containing such genes. Nature Publishing Group 2016-06 2016-06-22 /pmc/articles/PMC4932652/ /pubmed/27329848 http://dx.doi.org/10.1038/emi.2016.62 Text en Copyright © 2016 Shanghai Shangyixun Cultural Communication Co., Ltd http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Yan, Meiying
Li, Xinlan
Liao, Qiaohong
Li, Fang
Zhang, Jing
Kan, Biao
The emergence and outbreak of multidrug-resistant typhoid fever in China
title The emergence and outbreak of multidrug-resistant typhoid fever in China
title_full The emergence and outbreak of multidrug-resistant typhoid fever in China
title_fullStr The emergence and outbreak of multidrug-resistant typhoid fever in China
title_full_unstemmed The emergence and outbreak of multidrug-resistant typhoid fever in China
title_short The emergence and outbreak of multidrug-resistant typhoid fever in China
title_sort emergence and outbreak of multidrug-resistant typhoid fever in china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932652/
https://www.ncbi.nlm.nih.gov/pubmed/27329848
http://dx.doi.org/10.1038/emi.2016.62
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