An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

After three decades of intensive research efforts, an effective vaccine against HIV-1 remains to be developed. Several broadly neutralizing antibodies to HIV-1, such as 10E8, recognize the membrane proximal external region (MPER) of the HIV-1 gp41 protein. Thus, the MPER is considered to be a very i...

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Detalles Bibliográficos
Autores principales: Sun, Zhiwu, Zhu, Yun, Wang, Qian, Ye, Ling, Dai, Yanyan, Su, Shan, Yu, Fei, Ying, Tianlei, Yang, Chinglai, Jiang, Shibo, Lu, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932654/
https://www.ncbi.nlm.nih.gov/pubmed/27329850
http://dx.doi.org/10.1038/emi.2016.86

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