Cargando…

Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

BACKGROUND: Meprin displays multiple functions in both health and disease, due in part to its broad proteolytic activity. In this report, we explored the clinical significance and functional relevance of the expression of meprin-ɑ (MEP1A) in colorectal cancer (CRC). METHODS: The mRNA and protein exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiao, Chen, Jian, Wang, Jingtao, Yu, Fudong, Zhao, Senlin, Zhang, Yu, Tang, Huamei, Peng, Zhihai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932728/ https://www.ncbi.nlm.nih.gov/pubmed/27378469 http://dx.doi.org/10.1186/s12885-016-2460-5

Ejemplares similares

Correction to: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer
por: Wang, Xiao, et al.
Publicado: (2018)

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
por: Broder, Claudia, et al.
Publicado: (2013)

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP
por: Becker-Pauly, Christoph, et al.
Publicado: (2017)

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
por: Jefferson, Tamara, et al.
Publicado: (2012)

The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion
por: Huguenin, Maya, et al.
Publicado: (2008)

A preliminary study of possible fibrotic role of meprin metalloproteases in scleroderma patients
por: Koçak, Ayşe, et al.
Publicado: (2021)

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
por: Bayly-Jones, Charles, et al.
Publicado: (2022)

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis
por: Oneda, Beatrice, et al.
Publicado: (2008)

Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
por: Bülck, Cynthia, et al.
Publicado: (2023)

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
por: Arnold, Philipp, et al.
Publicado: (2017)

Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer
por: Wang, Jingtao, et al.
Publicado: (2015)

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α(2)
por: Schütte, André, et al.
Publicado: (2010)

MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
por: Cheng, Dantong, et al.
Publicado: (2016)

Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy
por: Cao, Lei, et al.
Publicado: (2018)

Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy
por: Gooding, Jessica, et al.
Publicado: (2019)

Zinc-α-2-Glycoprotein: A Candidate Biomarker for Colon Cancer Diagnosis in Chinese Population
por: Xue, Yingming, et al.
Publicado: (2014)

PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy
por: Chen, Jian, et al.
Publicado: (2014)

Origin and Diversification of Meprin Proteases
por: Marín, Ignacio
Publicado: (2015)

Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes
por: Bylander, John E., et al.
Publicado: (2017)

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro
por: Bedau, Tillmann, et al.
Publicado: (2017)

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach
por: Tan, Kathrin, et al.
Publicado: (2020)

Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer
por: Zhang, Yu, et al.
Publicado: (2015)

Distinct contributions of meprins to skin regeneration after injury – Meprin α a physiological processer of pro-collagen VII
por: Kruppa, Daniel, et al.
Publicado: (2021)

Erratum to “Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes”
por: Bylander, John E., et al.
Publicado: (2018)

A comparative analysis and guidance for individualized chemotherapy of stage II and III colorectal cancer patients based on pathological markers
por: Han, Yang, et al.
Publicado: (2016)

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
por: Lottaz, Daniel, et al.
Publicado: (2011)

Genome-Wide Identification of M35 Family Metalloproteases in Rhizoctonia cerealis and Functional Analysis of RcMEP2 as a Virulence Factor during the Fungal Infection to Wheat
por: Pan, Lijun, et al.
Publicado: (2020)

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin
por: Breig, Osman, et al.
Publicado: (2016)

Meprin β contributes to collagen deposition in lung fibrosis
por: Biasin, V., et al.
Publicado: (2017)

New links for meprin β within the protease web
por: Canbay, Vahap, et al.
Publicado: (2022)

The putative pleiotropic functions of meprin β in gastric cancer
por: Siemsen, Wiebke, et al.
Publicado: (2023)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)
por: Hou, Shurong, et al.
Publicado: (2021)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)
por: Wang, Chao, et al.
Publicado: (2021)

Developmental pluripotency-associated 4: a novel predictor for prognosis and a potential therapeutic target for colon cancer
por: Zhang, Meng, et al.
Publicado: (2015)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
por: Linnert, Miriam, et al.
Publicado: (2021)

Proteolytic processing and inactivation of CCL2/MCP-1 by meprins
por: Herzog, Christian, et al.
Publicado: (2016)

Evolution and Expression of the Meprin and TRAF Homology Domain-Containing Gene Family in Solanaceae
por: Dai, Yangshuo, et al.
Publicado: (2023)

Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases
por: Karmilin, Konstantin, et al.
Publicado: (2019)

Revit MEP 2018 : curso práctico /
por: Peña Arribas, Luis Carlos de la
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4unhk990kcfpkour9j1kal0eaj