Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies

A series of studies by Drs. Barak Caine, James Woods, Gregory Collins, Jonathan Katz and Takato Hiranita demonstrated a novel and unique reinforcing effect using dopamine (DA) D2-like receptor [D2-like R: D(2), D(3), and D(4) receptor subtypes (respectively, D(2)R, D(3)R, and D(4)R)] agonists in rat...

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Detalles Bibliográficos
Autores principales: Hiranita, Takato, Collins, Gregory T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932862/
https://www.ncbi.nlm.nih.gov/pubmed/27390753
http://dx.doi.org/10.4172/2329-6488.1000e124
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author Hiranita, Takato
Collins, Gregory T
author_facet Hiranita, Takato
Collins, Gregory T
author_sort Hiranita, Takato
collection PubMed
description A series of studies by Drs. Barak Caine, James Woods, Gregory Collins, Jonathan Katz and Takato Hiranita demonstrated a novel and unique reinforcing effect using dopamine (DA) D2-like receptor [D2-like R: D(2), D(3), and D(4) receptor subtypes (respectively, D(2)R, D(3)R, and D(4)R)] agonists in rats and genetically modified mice. In order to understand how important their findings are, a comparison was made regarding the reinforcing effects of DA D2-like R full agonists with those of DA uptake inhibitors and of a DA D1-like receptor [D1-like R, D(1) and D(5) receptor subtypes (D(1)R and D(5)R)] full agonist (±)-SKF 82958.
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spelling pubmed-49328622016-07-05 Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies Hiranita, Takato Collins, Gregory T J Alcohol Drug Depend Article A series of studies by Drs. Barak Caine, James Woods, Gregory Collins, Jonathan Katz and Takato Hiranita demonstrated a novel and unique reinforcing effect using dopamine (DA) D2-like receptor [D2-like R: D(2), D(3), and D(4) receptor subtypes (respectively, D(2)R, D(3)R, and D(4)R)] agonists in rats and genetically modified mice. In order to understand how important their findings are, a comparison was made regarding the reinforcing effects of DA D2-like R full agonists with those of DA uptake inhibitors and of a DA D1-like receptor [D1-like R, D(1) and D(5) receptor subtypes (D(1)R and D(5)R)] full agonist (±)-SKF 82958. 2015-07-25 2015-08 /pmc/articles/PMC4932862/ /pubmed/27390753 http://dx.doi.org/10.4172/2329-6488.1000e124 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Hiranita, Takato
Collins, Gregory T
Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies
title Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies
title_full Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies
title_fullStr Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies
title_full_unstemmed Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies
title_short Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies
title_sort differential roles for dopamine d1-like and d2-like receptors in mediating the reinforcing effects of cocaine: convergent evidence from pharmacological and genetic studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932862/
https://www.ncbi.nlm.nih.gov/pubmed/27390753
http://dx.doi.org/10.4172/2329-6488.1000e124
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