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An Optimal Bahadur-Efficient Method in Detection of Sparse Signals with Applications to Pathway Analysis in Sequencing Association Studies
Next-generation sequencing data pose a severe curse of dimensionality, complicating traditional "single marker—single trait" analysis. We propose a two-stage combined p-value method for pathway analysis. The first stage is at the gene level, where we integrate effects within a gene using t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933358/ https://www.ncbi.nlm.nih.gov/pubmed/27380176 http://dx.doi.org/10.1371/journal.pone.0152667 |