Cargando…

Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats

BACKGROUND: The platelet-derived growth factor receptor β (PDGFRβ)+ perivascular cell activation becomes increasingly recognized as a main source of scar-associated kidney myofibroblasts and recently emerged as a new cellular therapeutic target. AIMS: In this regard, we first confirmed the presence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pozdzik, Agnieszka A., Giordano, Laetitia, Li, Gang, Antoine, Marie-Hélène, Quellard, Nathalie, Godet, Julie, De Prez, Eric, Husson, Cécile, Declèves, Anne-Emilie, Arlt, Volker M., Goujon, Jean-Michel, Brochériou-Spelle, Isabelle, Ledbetter, Steven R., Caron, Nathalie, Nortier, Joëlle L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933370/ https://www.ncbi.nlm.nih.gov/pubmed/27379382 http://dx.doi.org/10.1371/journal.pone.0157288

Ejemplares similares

Experimental Aristolochic Acid Nephropathy: A Relevant Model to Study AKI-to-CKD Transition
por: Baudoux, Thomas, et al.
Publicado: (2022)

An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature
por: Jadot, Inès, et al.
Publicado: (2017)

CD146 is essential for PDGFRβ-induced pericyte recruitment
por: Chen, Jianan, et al.
Publicado: (2017)

CD4(+) and CD8(+) T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy
por: Baudoux, Thomas, et al.
Publicado: (2018)

Restored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy
por: Jadot, Inès, et al.
Publicado: (2017)

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes
por: Jansson, Deidre, et al.
Publicado: (2016)

M2 Macrophages Promote PDGFRβ(+) Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway
por: Li, Ziyu, et al.
Publicado: (2021)

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
por: Sborchia, Mateja, et al.
Publicado: (2019)

Spatiotemporal dynamics of PDGFRβ expression in pericytes and glial scar formation in penetrating brain injuries in adults
por: Reeves, C., et al.
Publicado: (2019)

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
por: Smyth, Leon C. D., et al.
Publicado: (2022)

Elevated PDGF‐BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes
por: Liu, Guanqiao, et al.
Publicado: (2023)

Protective Effect of Nebivolol against Oxidative Stress Induced by Aristolochic Acids in Endothelial Cells
por: Antoine, Marie-Hélène, et al.
Publicado: (2022)

Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
por: Craggs, Lucinda J.L., et al.
Publicado: (2015)

Ursodeoxycholic Acid Attenuates the Retinal Vascular Abnormalities in Anti-PDGFR-β Antibody-Induced Pericyte Depletion Mouse Models
por: Shiraya, Tomoyasu, et al.
Publicado: (2020)

PDGFR‐β and kidney fibrosis
por: Ortiz, Alberto
Publicado: (2020)

Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization
por: Chi, Sum Shing, et al.
Publicado: (2010)

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models
por: Lee, Seok Jae, et al.
Publicado: (2021)

Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the in vivo Antitumor Effects of Human TRAIL
por: Tao, Ze, et al.
Publicado: (2017)

Azathioprine as successful maintenance therapy in IgG4-related tubulointerstitial nephritis
por: Pozdzik, Agnieszka A., et al.
Publicado: (2012)

Membranous Nephropathy and Anti-Podocytes Antibodies: Implications for the Diagnostic Workup and Disease Management
por: Pozdzik, Agnieszka, et al.
Publicado: (2018)

Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke
por: Shibahara, Tomoya, et al.
Publicado: (2020)

Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury
por: Yao, Fei, et al.
Publicado: (2022)

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
por: Fantauzzo, Katherine A., et al.
Publicado: (2016)

Interferon-β1a-Induced Thrombotic Microangiopathy: Possible Implication of the Alternative Pathway of the Complement
por: Taghavi, Maxime, et al.
Publicado: (2022)

ARF sees Pdgfrβ through the miR
por: Reed, Sara M, et al.
Publicado: (2014)

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis
por: Buhl, Eva M, et al.
Publicado: (2020)

Diffusion-weighted magnetic resonance imaging as a new diagnostic tool of subclinical IgG4-related acute tubulointerstitial nephritis
por: Pozdzik, Agnieszka A., et al.
Publicado: (2013)

Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats
por: Bárta, František, et al.
Publicado: (2021)

Blockade of PDGFR-β Activation Eliminates Morphine Analgesic Tolerance
por: Wang, Yan, et al.
Publicado: (2012)

Ephrin-B2 controls PDGFRβ internalization and signaling
por: Nakayama, Akiko, et al.
Publicado: (2013)

Laminin regulates PDGFRβ(+) cell stemness and muscle development
por: Yao, Yao, et al.
Publicado: (2016)

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
por: Sorrentino, Vincenzo, et al.
Publicado: (2017)

Renal Protective Effects of 17β-Estradiol on Mice with Acute Aristolochic Acid Nephropathy
por: Shi, Min, et al.
Publicado: (2016)

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo
por: Sborchia, Mateja, et al.
Publicado: (2019)

Neonatal pancreatic pericytes support β-cell proliferation
por: Epshtein, Alona, et al.
Publicado: (2017)

Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ
por: O’Sullivan, Susannah, et al.
Publicado: (2016)

Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma
por: Frödin, Magnus, et al.
Publicado: (2017)

Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway
por: Wang, Yi-Chun, et al.
Publicado: (2019)

LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter
por: Wang, Yichun, et al.
Publicado: (2023)

PDGFRβ signaling regulates local inflammation and synergizes with hypercholesterolemia to promote atherosclerosis
por: He, Chaoyong, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_29j45ia5kjm1nghoquef0mpsp2