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Long noncoding RNAs and Alzheimer’s disease
Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933566/ https://www.ncbi.nlm.nih.gov/pubmed/27418812 http://dx.doi.org/10.2147/CIA.S107037 |
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author | Luo, Qiong Chen, Yinghui |
author_facet | Luo, Qiong Chen, Yinghui |
author_sort | Luo, Qiong |
collection | PubMed |
description | Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer’s disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer’s disease and focus on some specific lncRNAs that may underlie Alzheimer’s disease pathophysiology and therefore could be potential therapeutic targets. |
format | Online Article Text |
id | pubmed-4933566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49335662016-07-14 Long noncoding RNAs and Alzheimer’s disease Luo, Qiong Chen, Yinghui Clin Interv Aging Review Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer’s disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer’s disease and focus on some specific lncRNAs that may underlie Alzheimer’s disease pathophysiology and therefore could be potential therapeutic targets. Dove Medical Press 2016-06-29 /pmc/articles/PMC4933566/ /pubmed/27418812 http://dx.doi.org/10.2147/CIA.S107037 Text en © 2016 Luo and Chen. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Luo, Qiong Chen, Yinghui Long noncoding RNAs and Alzheimer’s disease |
title | Long noncoding RNAs and Alzheimer’s disease |
title_full | Long noncoding RNAs and Alzheimer’s disease |
title_fullStr | Long noncoding RNAs and Alzheimer’s disease |
title_full_unstemmed | Long noncoding RNAs and Alzheimer’s disease |
title_short | Long noncoding RNAs and Alzheimer’s disease |
title_sort | long noncoding rnas and alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933566/ https://www.ncbi.nlm.nih.gov/pubmed/27418812 http://dx.doi.org/10.2147/CIA.S107037 |
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