Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age‐associated alterations in heart rate variability in vivo

We aimed to determine how age‐associated changes in mechanisms extrinsic and intrinsic to pacemaker cells relate to basal beating interval variability (BIV) reduction in vivo. Beating intervals (BIs) were measured in aged (23–25 months) and adult (3–4 months) C57BL/6 male mice (i) via ECG in vivo du...

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Detalles Bibliográficos
Autores principales: Yaniv, Yael, Ahmet, Ismayil, Tsutsui, Kenta, Behar, Joachim, Moen, Jack M., Okamoto, Yosuke, Guiriba, Toni‐Rose, Liu, Jie, Bychkov, Rostislav, Lakatta, Edward G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933656/
https://www.ncbi.nlm.nih.gov/pubmed/27168363
http://dx.doi.org/10.1111/acel.12483

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