Dysfunctional telomeres induce p53‐dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation

Aging is associated with progressive telomere shortening, resulting in the formation of dysfunctional telomeres that compromise tissue proliferation. However, dysfunctional telomeres can limit tumorigenesis by activating p53‐dependent cellular senescence and apoptosis. While activation of both senes...

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Detalles Bibliográficos
Autores principales: Wang, Yang, Wang, Xinwei, Flores, Elsa R., Yu, Jian, Chang, Sandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933665/
https://www.ncbi.nlm.nih.gov/pubmed/27113195
http://dx.doi.org/10.1111/acel.12476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933665/
https://www.ncbi.nlm.nih.gov/pubmed/27113195
http://dx.doi.org/10.1111/acel.12476

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