Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis—A Hypothesis

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG codon repeat region in the HTT gene's first exon that results in huntingtin protein aggregation and neuronal cell death. The development of therapeutic treatments for HD is hinder...

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Detalles Bibliográficos
Autores principales: Nissley, Daniel A., O'Brien, Edward P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933702/
https://www.ncbi.nlm.nih.gov/pubmed/27458341
http://dx.doi.org/10.3389/fnmol.2016.00054

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