Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3′UTR in human liver cells

AIM: Increasing evidence shows that mRNAs exert regulatory function along with coding proteins. Recently we report that a hairpin within YAP mRNA 3′UTR can modulate the Hippo signaling pathway. PTEN is a tumor suppressor, and is mutated in human cancers. In this study we examined whether PTEN mRNA 3...

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Detalles Bibliográficos
Autores principales: Gao, Yu-en, Wang, Yuan, Chen, Fu-quan, Feng, Jin-yan, Yang, Guang, Feng, Guo-xing, Yang, Zhe, Ye, Li-hong, Zhang, Xiao-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933753/
https://www.ncbi.nlm.nih.gov/pubmed/27133296
http://dx.doi.org/10.1038/aps.2016.18

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