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Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder

Internet gaming disorder (IGD) has become a serious mental health issue worldwide. Evaluating the benefits of interventions for IGD is of great significance. Thirty-six young adults with IGD and 19 healthy comparison (HC) subjects were recruited and underwent resting-state fMRI scanning. Twenty IGD...

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Autores principales: Zhang, Jin-Tao, Yao, Yuan-Wei, Potenza, Marc N., Xia, Cui-Cui, Lan, Jing, Liu, Lu, Wang, Ling-Jiao, Liu, Ben, Ma, Shan-Shan, Fang, Xiao-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933876/
https://www.ncbi.nlm.nih.gov/pubmed/27381822
http://dx.doi.org/10.1038/srep28109
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author Zhang, Jin-Tao
Yao, Yuan-Wei
Potenza, Marc N.
Xia, Cui-Cui
Lan, Jing
Liu, Lu
Wang, Ling-Jiao
Liu, Ben
Ma, Shan-Shan
Fang, Xiao-Yi
author_facet Zhang, Jin-Tao
Yao, Yuan-Wei
Potenza, Marc N.
Xia, Cui-Cui
Lan, Jing
Liu, Lu
Wang, Ling-Jiao
Liu, Ben
Ma, Shan-Shan
Fang, Xiao-Yi
author_sort Zhang, Jin-Tao
collection PubMed
description Internet gaming disorder (IGD) has become a serious mental health issue worldwide. Evaluating the benefits of interventions for IGD is of great significance. Thirty-six young adults with IGD and 19 healthy comparison (HC) subjects were recruited and underwent resting-state fMRI scanning. Twenty IGD subjects participated in a group craving behavioral intervention (CBI) and were scanned before and after the intervention. The remaining 16 IGD subjects did not receive an intervention. The results showed that IGD subjects showed decreased amplitude of low fluctuation in the orbital frontal cortex and posterior cingulate cortex, and exhibited increased resting-state functional connectivity between the posterior cingulate cortex and dorsolateral prefrontal cortex, compared with HC subjects. Compared with IGD subjects who did not receive the intervention, those receiving CBI demonstrated significantly reduced resting-state functional connectivity between the: (1) orbital frontal cortex with hippocampus/parahippocampal gyrus; and, (2) posterior cingulate cortex with supplementary motor area, precentral gyrus, and postcentral gyrus. These findings suggest that IGD is associated with abnormal resting-state neural activity in reward-related, default mode and executive control networks. Thus, the CBI may exert effects by reducing interactions between regions within a reward-related network, and across the default mode and executive control networks.
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spelling pubmed-49338762016-07-08 Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder Zhang, Jin-Tao Yao, Yuan-Wei Potenza, Marc N. Xia, Cui-Cui Lan, Jing Liu, Lu Wang, Ling-Jiao Liu, Ben Ma, Shan-Shan Fang, Xiao-Yi Sci Rep Article Internet gaming disorder (IGD) has become a serious mental health issue worldwide. Evaluating the benefits of interventions for IGD is of great significance. Thirty-six young adults with IGD and 19 healthy comparison (HC) subjects were recruited and underwent resting-state fMRI scanning. Twenty IGD subjects participated in a group craving behavioral intervention (CBI) and were scanned before and after the intervention. The remaining 16 IGD subjects did not receive an intervention. The results showed that IGD subjects showed decreased amplitude of low fluctuation in the orbital frontal cortex and posterior cingulate cortex, and exhibited increased resting-state functional connectivity between the posterior cingulate cortex and dorsolateral prefrontal cortex, compared with HC subjects. Compared with IGD subjects who did not receive the intervention, those receiving CBI demonstrated significantly reduced resting-state functional connectivity between the: (1) orbital frontal cortex with hippocampus/parahippocampal gyrus; and, (2) posterior cingulate cortex with supplementary motor area, precentral gyrus, and postcentral gyrus. These findings suggest that IGD is associated with abnormal resting-state neural activity in reward-related, default mode and executive control networks. Thus, the CBI may exert effects by reducing interactions between regions within a reward-related network, and across the default mode and executive control networks. Nature Publishing Group 2016-07-06 /pmc/articles/PMC4933876/ /pubmed/27381822 http://dx.doi.org/10.1038/srep28109 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Jin-Tao
Yao, Yuan-Wei
Potenza, Marc N.
Xia, Cui-Cui
Lan, Jing
Liu, Lu
Wang, Ling-Jiao
Liu, Ben
Ma, Shan-Shan
Fang, Xiao-Yi
Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder
title Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder
title_full Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder
title_fullStr Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder
title_full_unstemmed Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder
title_short Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder
title_sort altered resting-state neural activity and changes following a craving behavioral intervention for internet gaming disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933876/
https://www.ncbi.nlm.nih.gov/pubmed/27381822
http://dx.doi.org/10.1038/srep28109
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