Integrated hollow microneedle-optofluidic biosensor for therapeutic drug monitoring in sub-nanoliter volumes

Therapeutic drug monitoring (TDM) typically requires painful blood drawn from patients. We propose a painless and minimally-invasive alternative for TDM using hollow microneedles suitable to extract extremely small volumes (<1 nL) of interstitial fluid to measure drug concentrations. The inner lu...

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Detalles Bibliográficos
Autores principales: Ranamukhaarachchi, Sahan A., Padeste, Celestino, Dübner, Matthias, Häfeli, Urs O., Stoeber, Boris, Cadarso, Victor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933911/
https://www.ncbi.nlm.nih.gov/pubmed/27380889
http://dx.doi.org/10.1038/srep29075

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