K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions

Mutational activation of K-Ras is an initiating event of pancreatic ductal adenocarcinomas (PDAC) that may develop either from pancreatic intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplasms (IPMN). Cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2)) is causally rel...

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Detalles Bibliográficos
Autores principales: Chiblak, Sara, Steinbauer, Brigitte, Pohl-Arnold, Andrea, Kucher, Dagmar, Abdollahi, Amir, Schwager, Christian, Höft, Birgit, Esposito, Irene, Müller-Decker, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933934/
https://www.ncbi.nlm.nih.gov/pubmed/27381829
http://dx.doi.org/10.1038/srep29455

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