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Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer

The special anatomical position accounts for unusual clinicopathological features of uncinate process cancer. This study aimed to compare clinicopathological features of patients with uncinate process cancer to patients with non-uncinate process pancreatic head cancer. Total 160 patients with pancre...

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Autores principales: Liu, Chang, Tian, Xiaodong, Xie, Xuehai, Gao, Hongqiao, Zhuang, Yan, Yang, Yinmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934032/
https://www.ncbi.nlm.nih.gov/pubmed/27390599
http://dx.doi.org/10.7150/jca.15062
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author Liu, Chang
Tian, Xiaodong
Xie, Xuehai
Gao, Hongqiao
Zhuang, Yan
Yang, Yinmo
author_facet Liu, Chang
Tian, Xiaodong
Xie, Xuehai
Gao, Hongqiao
Zhuang, Yan
Yang, Yinmo
author_sort Liu, Chang
collection PubMed
description The special anatomical position accounts for unusual clinicopathological features of uncinate process cancer. This study aimed to compare clinicopathological features of patients with uncinate process cancer to patients with non-uncinate process pancreatic head cancer. Total 160 patients with pancreatic head cancer were enrolled and classified into two groups: uncinate process cancer and non-uncinate process pancreatic head cancer. We found that the ratio of vascular invasion was significantly higher in patients with uncinate process cancer than in patients with non-uncinate process pancreatic head cancer. In addition, the rate of R1 resection was significantly higher in patients with uncinate process cancer. Furthermore, the median disease-free survival (11 months vs. 15 months, p=0.043) and overall survival (15 months vs. 19 months, p=0.036) after R0 resection were lower for uncinate process cancer. Locoregional recurrence was more frequent (p=0.017) and earlier (12 months vs. 36 months; p=0.002) in patients with uncinate process cancer than in patients with non-uncinate process pancreatic head cancer. In conclusion, uncinate process cancer is more likely to invade blood vessel and has worse prognosis due to the earlier and more frequent locoregional recurrence.
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spelling pubmed-49340322016-07-07 Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer Liu, Chang Tian, Xiaodong Xie, Xuehai Gao, Hongqiao Zhuang, Yan Yang, Yinmo J Cancer Research Paper The special anatomical position accounts for unusual clinicopathological features of uncinate process cancer. This study aimed to compare clinicopathological features of patients with uncinate process cancer to patients with non-uncinate process pancreatic head cancer. Total 160 patients with pancreatic head cancer were enrolled and classified into two groups: uncinate process cancer and non-uncinate process pancreatic head cancer. We found that the ratio of vascular invasion was significantly higher in patients with uncinate process cancer than in patients with non-uncinate process pancreatic head cancer. In addition, the rate of R1 resection was significantly higher in patients with uncinate process cancer. Furthermore, the median disease-free survival (11 months vs. 15 months, p=0.043) and overall survival (15 months vs. 19 months, p=0.036) after R0 resection were lower for uncinate process cancer. Locoregional recurrence was more frequent (p=0.017) and earlier (12 months vs. 36 months; p=0.002) in patients with uncinate process cancer than in patients with non-uncinate process pancreatic head cancer. In conclusion, uncinate process cancer is more likely to invade blood vessel and has worse prognosis due to the earlier and more frequent locoregional recurrence. Ivyspring International Publisher 2016-06-21 /pmc/articles/PMC4934032/ /pubmed/27390599 http://dx.doi.org/10.7150/jca.15062 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Research Paper
Liu, Chang
Tian, Xiaodong
Xie, Xuehai
Gao, Hongqiao
Zhuang, Yan
Yang, Yinmo
Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer
title Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer
title_full Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer
title_fullStr Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer
title_full_unstemmed Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer
title_short Comparison of Uncinate Process Cancer and Non-Uncinate Process Pancreatic Head Cancer
title_sort comparison of uncinate process cancer and non-uncinate process pancreatic head cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934032/
https://www.ncbi.nlm.nih.gov/pubmed/27390599
http://dx.doi.org/10.7150/jca.15062
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