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Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring

A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing meth...

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Detalles Bibliográficos
Autores principales: Ren, Lei, Jiang, Qing, Chen, Keyun, Chen, Zhipeng, Pan, Chengfeng, Jiang, Lelun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934334/
https://www.ncbi.nlm.nih.gov/pubmed/27322278
http://dx.doi.org/10.3390/s16060908
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author Ren, Lei
Jiang, Qing
Chen, Keyun
Chen, Zhipeng
Pan, Chengfeng
Jiang, Lelun
author_facet Ren, Lei
Jiang, Qing
Chen, Keyun
Chen, Zhipeng
Pan, Chengfeng
Jiang, Lelun
author_sort Ren, Lei
collection PubMed
description A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing method. The MA was composed of 6 × 6 micro-needles with an average height of about 500 μm. Electrode-skin interface impedance (EII) was recorded as the insertion force was applied on the MAE. The insertion process of the MAE was also simulated by the finite element method. Results showed that MAE could insert into skin with a relatively low compression force and maintain stable contact impedance between the MAE and skin. Bio-signals, including electromyography (EMG), electrocardiography (ECG), and electroencephalograph (EEG) were also collected. Test results showed that the MAE could record EMG, ECG, and EEG signals with good fidelity in shape and amplitude in comparison with the commercial Ag/AgCl electrodes, which proves that MAE is an alternative electrode for bio-signals monitoring.
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spelling pubmed-49343342016-07-06 Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring Ren, Lei Jiang, Qing Chen, Keyun Chen, Zhipeng Pan, Chengfeng Jiang, Lelun Sensors (Basel) Article A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing method. The MA was composed of 6 × 6 micro-needles with an average height of about 500 μm. Electrode-skin interface impedance (EII) was recorded as the insertion force was applied on the MAE. The insertion process of the MAE was also simulated by the finite element method. Results showed that MAE could insert into skin with a relatively low compression force and maintain stable contact impedance between the MAE and skin. Bio-signals, including electromyography (EMG), electrocardiography (ECG), and electroencephalograph (EEG) were also collected. Test results showed that the MAE could record EMG, ECG, and EEG signals with good fidelity in shape and amplitude in comparison with the commercial Ag/AgCl electrodes, which proves that MAE is an alternative electrode for bio-signals monitoring. MDPI 2016-06-17 /pmc/articles/PMC4934334/ /pubmed/27322278 http://dx.doi.org/10.3390/s16060908 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ren, Lei
Jiang, Qing
Chen, Keyun
Chen, Zhipeng
Pan, Chengfeng
Jiang, Lelun
Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring
title Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring
title_full Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring
title_fullStr Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring
title_full_unstemmed Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring
title_short Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring
title_sort fabrication of a micro-needle array electrode by thermal drawing for bio-signals monitoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934334/
https://www.ncbi.nlm.nih.gov/pubmed/27322278
http://dx.doi.org/10.3390/s16060908
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