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Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients

Real-time monitoring and precise diagnosis of the severity of Dengue infection is needed for better decisions in disease management. The aim of this study is to use the Bioimpedance Vector Analysis (BIVA) method to differentiate between healthy subjects and severe and non-severe Dengue-infected pati...

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Autores principales: Khalil, Sami F., Mohktar, Mas S., Ibrahim, Fatimah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934337/
https://www.ncbi.nlm.nih.gov/pubmed/27322285
http://dx.doi.org/10.3390/s16060911
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author Khalil, Sami F.
Mohktar, Mas S.
Ibrahim, Fatimah
author_facet Khalil, Sami F.
Mohktar, Mas S.
Ibrahim, Fatimah
author_sort Khalil, Sami F.
collection PubMed
description Real-time monitoring and precise diagnosis of the severity of Dengue infection is needed for better decisions in disease management. The aim of this study is to use the Bioimpedance Vector Analysis (BIVA) method to differentiate between healthy subjects and severe and non-severe Dengue-infected patients. Bioimpedance was measured using a 50 KHz single-frequency bioimpedance analyzer. Data from 299 healthy subjects (124 males and 175 females) and 205 serologically confirmed Dengue patients (123 males and 82 females) were analyzed in this study. The obtained results show that the BIVA method was able to assess and classify the body fluid and cell mass condition between the healthy subjects and the Dengue-infected patients. The bioimpedance mean vectors (95% confidence ellipse) for healthy subjects, severe and non-severe Dengue-infected patients were illustrated. The vector is significantly shortened from healthy subjects to Dengue patients; for both genders the p-value is less than 0.0001. The mean vector of severe Dengue patients is significantly shortened compare to non-severe patients with a p-value of 0.0037 and 0.0023 for males and females, respectively. This study confirms that the BIVA method is a valid method in differentiating the healthy, severe and non-severe Dengue-infected subjects. All tests performed had a significance level with a p-value less than 0.05.
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spelling pubmed-49343372016-07-06 Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients Khalil, Sami F. Mohktar, Mas S. Ibrahim, Fatimah Sensors (Basel) Article Real-time monitoring and precise diagnosis of the severity of Dengue infection is needed for better decisions in disease management. The aim of this study is to use the Bioimpedance Vector Analysis (BIVA) method to differentiate between healthy subjects and severe and non-severe Dengue-infected patients. Bioimpedance was measured using a 50 KHz single-frequency bioimpedance analyzer. Data from 299 healthy subjects (124 males and 175 females) and 205 serologically confirmed Dengue patients (123 males and 82 females) were analyzed in this study. The obtained results show that the BIVA method was able to assess and classify the body fluid and cell mass condition between the healthy subjects and the Dengue-infected patients. The bioimpedance mean vectors (95% confidence ellipse) for healthy subjects, severe and non-severe Dengue-infected patients were illustrated. The vector is significantly shortened from healthy subjects to Dengue patients; for both genders the p-value is less than 0.0001. The mean vector of severe Dengue patients is significantly shortened compare to non-severe patients with a p-value of 0.0037 and 0.0023 for males and females, respectively. This study confirms that the BIVA method is a valid method in differentiating the healthy, severe and non-severe Dengue-infected subjects. All tests performed had a significance level with a p-value less than 0.05. MDPI 2016-06-18 /pmc/articles/PMC4934337/ /pubmed/27322285 http://dx.doi.org/10.3390/s16060911 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khalil, Sami F.
Mohktar, Mas S.
Ibrahim, Fatimah
Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients
title Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients
title_full Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients
title_fullStr Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients
title_full_unstemmed Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients
title_short Bioimpedance Vector Analysis in Diagnosing Severe and Non-Severe Dengue Patients
title_sort bioimpedance vector analysis in diagnosing severe and non-severe dengue patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934337/
https://www.ncbi.nlm.nih.gov/pubmed/27322285
http://dx.doi.org/10.3390/s16060911
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