TGF-β1, in association with the increased expression of connective tissue growth factor, induce the hypertrophy of the ligamentum flavum through the p38 MAPK pathway

Hypertrophy of the ligamentum flavum (LF) is one of the key pathomechanisms of lumbar spinal stenosis (LSS). Transforming growth factor (TGF)-β1 is abundantly expressed in hypertrophied degenerative LF tissues from LSS. However, the molecular mechanisms underling the association between TGF-β1 and L...

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Detalles Bibliográficos
Autores principales: Cao, Yan-Lin, Duan, Yang, Zhu, Li-Xin, Zhan, Ye-Nan, Min, Shao-Xiong, Jin, An-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935458/
https://www.ncbi.nlm.nih.gov/pubmed/27279555
http://dx.doi.org/10.3892/ijmm.2016.2631

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