A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structur...

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Detalles Bibliográficos
Autores principales: Arenz, Stefan, Bock, Lars V., Graf, Michael, Innis, C. Axel, Beckmann, Roland, Grubmüller, Helmut, Vaiana, Andrea C., Wilson, Daniel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935803/
https://www.ncbi.nlm.nih.gov/pubmed/27380950
http://dx.doi.org/10.1038/ncomms12026

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