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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associate...

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Autores principales: Bronte, Vincenzo, Brandau, Sven, Chen, Shu-Hsia, Colombo, Mario P., Frey, Alan B., Greten, Tim F., Mandruzzato, Susanna, Murray, Peter J., Ochoa, Augusto, Ostrand-Rosenberg, Suzanne, Rodriguez, Paulo C., Sica, Antonio, Umansky, Viktor, Vonderheide, Robert H., Gabrilovich, Dmitry I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935811/
https://www.ncbi.nlm.nih.gov/pubmed/27381735
http://dx.doi.org/10.1038/ncomms12150
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author Bronte, Vincenzo
Brandau, Sven
Chen, Shu-Hsia
Colombo, Mario P.
Frey, Alan B.
Greten, Tim F.
Mandruzzato, Susanna
Murray, Peter J.
Ochoa, Augusto
Ostrand-Rosenberg, Suzanne
Rodriguez, Paulo C.
Sica, Antonio
Umansky, Viktor
Vonderheide, Robert H.
Gabrilovich, Dmitry I.
author_facet Bronte, Vincenzo
Brandau, Sven
Chen, Shu-Hsia
Colombo, Mario P.
Frey, Alan B.
Greten, Tim F.
Mandruzzato, Susanna
Murray, Peter J.
Ochoa, Augusto
Ostrand-Rosenberg, Suzanne
Rodriguez, Paulo C.
Sica, Antonio
Umansky, Viktor
Vonderheide, Robert H.
Gabrilovich, Dmitry I.
author_sort Bronte, Vincenzo
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.
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spelling pubmed-49358112016-07-14 Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards Bronte, Vincenzo Brandau, Sven Chen, Shu-Hsia Colombo, Mario P. Frey, Alan B. Greten, Tim F. Mandruzzato, Susanna Murray, Peter J. Ochoa, Augusto Ostrand-Rosenberg, Suzanne Rodriguez, Paulo C. Sica, Antonio Umansky, Viktor Vonderheide, Robert H. Gabrilovich, Dmitry I. Nat Commun Review Article Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research. Nature Publishing Group 2016-07-06 /pmc/articles/PMC4935811/ /pubmed/27381735 http://dx.doi.org/10.1038/ncomms12150 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Bronte, Vincenzo
Brandau, Sven
Chen, Shu-Hsia
Colombo, Mario P.
Frey, Alan B.
Greten, Tim F.
Mandruzzato, Susanna
Murray, Peter J.
Ochoa, Augusto
Ostrand-Rosenberg, Suzanne
Rodriguez, Paulo C.
Sica, Antonio
Umansky, Viktor
Vonderheide, Robert H.
Gabrilovich, Dmitry I.
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_full Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_fullStr Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_full_unstemmed Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_short Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
title_sort recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935811/
https://www.ncbi.nlm.nih.gov/pubmed/27381735
http://dx.doi.org/10.1038/ncomms12150
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