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Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML
The BMAL1 and CLOCK heterodimer in the mammalian circadian transcriptional complex is thought to be repressed by PER2 and CRY1 via direct interactions. We recently reported that PER2 is largely cytosolic in Pml(−/−) cells and did not co-immunoprecipitate (co-IP) with BMAL1 or CLOCK. Here, using mult...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935866/ https://www.ncbi.nlm.nih.gov/pubmed/27383066 http://dx.doi.org/10.1038/srep29174 |