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Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

Microglia are activated following cerebral ischemia and increase their production of the neuro- and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function of TNF from this cellular source in focal cerebral ischemia we used TNF conditional knock out mice (LysMcreTNF(fl/fl)) in...

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Detalles Bibliográficos
Autores principales:	Clausen, Bettina Hjelm, Degn, Matilda, Sivasaravanaparan, Mithula, Fogtmann, Torben, Andersen, Maria Gammelstrup, Trojanowsky, Michelle D., Gao, Han, Hvidsten, Svend, Baun, Christina, Deierborg, Tomas, Finsen, Bente, Kristensen, Bjarne Winther, Bak, Sara Thornby, Meyer, Morten, Lee, Jae, Nedospasov, Sergei A., Brambilla, Roberta, Lambertsen, Kate Lykke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935869/ https://www.ncbi.nlm.nih.gov/pubmed/27384243 http://dx.doi.org/10.1038/srep29291

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