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Fabrication of water-soluble polymer-encapsulated As(4)S(4) to increase oral bioavailability and chemotherapeutic efficacy in AML mice
Realgar (As(4)S(4)) has been demonstrated to be effective for the treatment of acute myeloid leukemia (AML); it has the advantages of no drug resistance and oral administration. Nevertheless, its poor solubility has been an obstacle to its bioavailability, requiring high-dose administration over a l...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935940/ https://www.ncbi.nlm.nih.gov/pubmed/27383126 http://dx.doi.org/10.1038/srep29348 |