Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, and show that TAF15 binds to ∼4,900 RNAs enriched for GGUA motifs in adult mo...

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Detalles Bibliográficos
Autores principales: Kapeli, Katannya, Pratt, Gabriel A., Vu, Anthony Q., Hutt, Kasey R., Martinez, Fernando J., Sundararaman, Balaji, Batra, Ranjan, Freese, Peter, Lambert, Nicole J., Huelga, Stephanie C., Chun, Seung J., Liang, Tiffany Y., Chang, Jeremy, Donohue, John P., Shiue, Lily, Zhang, Jiayu, Zhu, Haining, Cambi, Franca, Kasarskis, Edward, Hoon, Shawn, Ares Jr., Manuel, Burge, Christopher B., Ravits, John, Rigo, Frank, Yeo, Gene W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935974/
https://www.ncbi.nlm.nih.gov/pubmed/27378374
http://dx.doi.org/10.1038/ncomms12143

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