A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

The precise role of the spliceosomal DEAD-box protein Prp28 in higher eukaryotes remains unclear. We show that stable tri-snRNP association during pre-catalytic spliceosomal B complex formation is blocked by a dominant-negative hPrp28 mutant lacking ATPase activity. Complexes formed in the presence...

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Detalles Bibliográficos
Autores principales: Boesler, Carsten, Rigo, Norbert, Anokhina, Maria M., Tauchert, Marcel J., Agafonov, Dmitry E., Kastner, Berthold, Urlaub, Henning, Ficner, Ralf, Will, Cindy L., Lührmann, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935976/
https://www.ncbi.nlm.nih.gov/pubmed/27377154
http://dx.doi.org/10.1038/ncomms11997

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