Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in mult...

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Autores principales: Mohty, M, Malard, F, Abecassis, M, Aerts, E, Alaskar, A S, Aljurf, M, Arat, M, Bader, P, Baron, F, Bazarbachi, A, Blaise, D, Ciceri, F, Corbacioglu, S, Dalle, J-H, Dignan, F, Fukuda, T, Huynh, A, Masszi, T, Michallet, M, Nagler, A, NiChonghaile, M, Okamoto, S, Pagliuca, A, Peters, C, Petersen, F B, Richardson, P G, Ruutu, T, Savani, B N, Wallhult, E, Yakoub-Agha, I, Duarte, R F, Carreras, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Special Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935979/
https://www.ncbi.nlm.nih.gov/pubmed/27183098
http://dx.doi.org/10.1038/bmt.2016.130
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author Mohty, M
Malard, F
Abecassis, M
Aerts, E
Alaskar, A S
Aljurf, M
Arat, M
Bader, P
Baron, F
Bazarbachi, A
Blaise, D
Ciceri, F
Corbacioglu, S
Dalle, J-H
Dignan, F
Fukuda, T
Huynh, A
Masszi, T
Michallet, M
Nagler, A
NiChonghaile, M
Okamoto, S
Pagliuca, A
Peters, C
Petersen, F B
Richardson, P G
Ruutu, T
Savani, B N
Wallhult, E
Yakoub-Agha, I
Duarte, R F
Carreras, E
author_facet Mohty, M
Malard, F
Abecassis, M
Aerts, E
Alaskar, A S
Aljurf, M
Arat, M
Bader, P
Baron, F
Bazarbachi, A
Blaise, D
Ciceri, F
Corbacioglu, S
Dalle, J-H
Dignan, F
Fukuda, T
Huynh, A
Masszi, T
Michallet, M
Nagler, A
NiChonghaile, M
Okamoto, S
Pagliuca, A
Peters, C
Petersen, F B
Richardson, P G
Ruutu, T
Savani, B N
Wallhult, E
Yakoub-Agha, I
Duarte, R F
Carreras, E
author_sort Mohty, M
collection PubMed
description Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.
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spelling pubmed-49359792016-07-18 Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation Mohty, M Malard, F Abecassis, M Aerts, E Alaskar, A S Aljurf, M Arat, M Bader, P Baron, F Bazarbachi, A Blaise, D Ciceri, F Corbacioglu, S Dalle, J-H Dignan, F Fukuda, T Huynh, A Masszi, T Michallet, M Nagler, A NiChonghaile, M Okamoto, S Pagliuca, A Peters, C Petersen, F B Richardson, P G Ruutu, T Savani, B N Wallhult, E Yakoub-Agha, I Duarte, R F Carreras, E Bone Marrow Transplant Special Report Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation. Nature Publishing Group 2016-07 2016-05-16 /pmc/articles/PMC4935979/ /pubmed/27183098 http://dx.doi.org/10.1038/bmt.2016.130 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Special Report
Mohty, M
Malard, F
Abecassis, M
Aerts, E
Alaskar, A S
Aljurf, M
Arat, M
Bader, P
Baron, F
Bazarbachi, A
Blaise, D
Ciceri, F
Corbacioglu, S
Dalle, J-H
Dignan, F
Fukuda, T
Huynh, A
Masszi, T
Michallet, M
Nagler, A
NiChonghaile, M
Okamoto, S
Pagliuca, A
Peters, C
Petersen, F B
Richardson, P G
Ruutu, T
Savani, B N
Wallhult, E
Yakoub-Agha, I
Duarte, R F
Carreras, E
Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation
title Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation
title_full Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation
title_fullStr Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation
title_full_unstemmed Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation
title_short Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation
title_sort revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the european society for blood and marrow transplantation
topic Special Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935979/
https://www.ncbi.nlm.nih.gov/pubmed/27183098
http://dx.doi.org/10.1038/bmt.2016.130
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