Cargando…
Glycoform-independent prion conversion by highly efficient, cell-based, protein misfolding cyclic amplification
Prions are formed of misfolded assemblies (PrP(Sc)) of the variably N-glycosylated cellular prion protein (PrP(C)). In infected species, prions replicate by seeding the conversion and polymerization of host PrP(C). Distinct prion strains can be recognized, exhibiting defined PrP(Sc) biochemical prop...
Autores principales: | Moudjou, Mohammed, Chapuis, Jérôme, Mekrouti, Mériem, Reine, Fabienne, Herzog, Laetitia, Sibille, Pierre, Laude, Hubert, Vilette, Didier, Andréoletti, Olivier, Rezaei, Human, Dron, Michel, Béringue, Vincent |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935985/ https://www.ncbi.nlm.nih.gov/pubmed/27384922 http://dx.doi.org/10.1038/srep29116 |
Ejemplares similares
-
Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification
por: Moudjou, Mohammed, et al.
Publicado: (2013) -
Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics
por: Laferrière, Florent, et al.
Publicado: (2013) -
Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions
por: Chapuis, Jérôme, et al.
Publicado: (2016) -
Prion strain-dependent tropism is maintained between spleen and granuloma and relies on lymphofollicular structures
por: Al-Dybiat, Iman, et al.
Publicado: (2019) -
Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?
por: Igel-Egalon, Angélique, et al.
Publicado: (2019)