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Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936117/ https://www.ncbi.nlm.nih.gov/pubmed/27386948 http://dx.doi.org/10.1186/s12885-016-2443-6 |
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| author | Kasuga, Jun Kawahara, Takashi Takamoto, Daiji Fukui, Sachi Tokita, Takashi Tadenuma, Tomoyuki Narahara, Masaki Fusayasu, Syusei Terao, Hideyuki Izumi, Koji Ito, Hiroki Hattori, Yusuke Teranishi, Jun-ichi Sasaki, Takeshi Makiyama, Kazuhide Miyoshi, Yasuhide Yao, Masahiro Yumura, Yasushi Miyamoto, Hiroshi Uemura, Hiroji |
| author_facet | Kasuga, Jun Kawahara, Takashi Takamoto, Daiji Fukui, Sachi Tokita, Takashi Tadenuma, Tomoyuki Narahara, Masaki Fusayasu, Syusei Terao, Hideyuki Izumi, Koji Ito, Hiroki Hattori, Yusuke Teranishi, Jun-ichi Sasaki, Takeshi Makiyama, Kazuhide Miyoshi, Yasuhide Yao, Masahiro Yumura, Yasushi Miyamoto, Hiroshi Uemura, Hiroji |
| author_sort | Kasuga, Jun |
| collection | PubMed |
| description | BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. METHODS: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. RESULTS: The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. CONCLUSIONS: The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer. |
| format | Online Article Text |
| id | pubmed-4936117 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49361172016-07-07 Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer Kasuga, Jun Kawahara, Takashi Takamoto, Daiji Fukui, Sachi Tokita, Takashi Tadenuma, Tomoyuki Narahara, Masaki Fusayasu, Syusei Terao, Hideyuki Izumi, Koji Ito, Hiroki Hattori, Yusuke Teranishi, Jun-ichi Sasaki, Takeshi Makiyama, Kazuhide Miyoshi, Yasuhide Yao, Masahiro Yumura, Yasushi Miyamoto, Hiroshi Uemura, Hiroji BMC Cancer Research Article BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. METHODS: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. RESULTS: The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. CONCLUSIONS: The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer. BioMed Central 2016-07-07 /pmc/articles/PMC4936117/ /pubmed/27386948 http://dx.doi.org/10.1186/s12885-016-2443-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Research Article Kasuga, Jun Kawahara, Takashi Takamoto, Daiji Fukui, Sachi Tokita, Takashi Tadenuma, Tomoyuki Narahara, Masaki Fusayasu, Syusei Terao, Hideyuki Izumi, Koji Ito, Hiroki Hattori, Yusuke Teranishi, Jun-ichi Sasaki, Takeshi Makiyama, Kazuhide Miyoshi, Yasuhide Yao, Masahiro Yumura, Yasushi Miyamoto, Hiroshi Uemura, Hiroji Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer |
| title | Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer |
| title_full | Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer |
| title_fullStr | Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer |
| title_full_unstemmed | Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer |
| title_short | Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer |
| title_sort | increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936117/ https://www.ncbi.nlm.nih.gov/pubmed/27386948 http://dx.doi.org/10.1186/s12885-016-2443-6 |
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